Exploring the Mechanism of Biological Evolution : DNA Methyltransferase is the Pushing Power for DNA and Protein Evolution

Seno, Masaharu

ISBN 10: 3844317252 / ISBN 13: 9783844317251

Published by LAP LAMBERT Academic Publishing, 2011

About this Item

Zustand: Hervorragend | Sprache: Englisch | Produktart: Bücher | DNA and protein evolution is the cornerstone of modern biology. In order to form a new integrated theory, the study incorporates many factors: (1) the large-scale random unequal crossover in eukaryote meiosis have fueled spliceosomal introns, which results in that introns are very common in eukaryotes but very less in prokaryotes; (2) DNA evolution proceeds through two ways: C-to-T (caused by DNA methyltransferase, which mainly existed in vertebrates) and A-to-G substitution (which increased linearly with the A/G gradient); (3) the trend of protein evolution is controlled by the simple trend of coding-DNA evolution. Cys increases in the all species during protein evolution; (4) S. thermophilus is tested to be resistant to most current antibiotics due to horizontal gene transfer; (5) DNA methyltransferase is considered to affect protein evolution, which will promote various cancers prevalence, thus an enzyme inhibitor could be a potential candidate for cancer therapy; (6) Meanwhile, multibase site-directed mutagenesis, heterogeneous DNA transformation and species selection are studied for exploring evolution.

Seller Inventory # 10541176/1

Bibliographic Details

• Title: Exploring the Mechanism of Biological Evolution : DNA Methyltransferase is the Pushing Power for DNA and Protein Evolution
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2011
• Language: English
• ISBN 10: 3844317252
• ISBN 13: 9783844317251
• Binding: Soft cover
• Condition: Hervorragend
• Seller catalogs:
  • Bücher

About this title

Synopsis

DNA and protein evolution is the cornerstone of modern biology. In order to form a new integrated theory, the study incorporates many factors: (1) the large-scale random unequal crossover in eukaryote meiosis have fueled spliceosomal introns, which results in that introns are very common in eukaryotes but very less in prokaryotes; (2) DNA evolution proceeds through two ways: C-to-T (caused by DNA methyltransferase, which mainly existed in vertebrates) and A-to-G substitution (which increased linearly with the A/G gradient); (3) the trend of protein evolution is controlled by the simple trend of coding-DNA evolution. Cys increases in the all species during protein evolution; (4) S. thermophilus is tested to be resistant to most current antibiotics due to horizontal gene transfer; (5) DNA methyltransferase is considered to affect protein evolution, which will promote various cancers prevalence, thus an enzyme inhibitor could be a potential candidate for cancer therapy; (6) Meanwhile, multibase site-directed mutagenesis, heterogeneous DNA transformation and species selection are studied for exploring evolution.

About the Author

Haidong Tan is an Associate Professor of Molecular Biology at Dalian Institute of Chemical Physics, CAS; Dalian Institute of Biotechnology, LACS. Masaharu Seno, PH.D, Vice Dean, Faculty of Engineering, Professor of Nano-Biotechnology Department of Medical and Bioengineering Science, Okayama University.