FORMULATION AND EVALUATION OF SIMVASTATIN TABLET: FAST DISSOLVING TABLET

PATEL, URVASHI; PATEL, HARSHIL

ISBN 10: 6200539138 / ISBN 13: 9786200539137

Published by LAP LAMBERT Academic Publishing, 2020

About this Item

Seller Inventory # I-9786200539137

Bibliographic Details

• Title: FORMULATION AND EVALUATION OF SIMVASTATIN TABLET: FAST DISSOLVING TABLET
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2020
• Language: English
• ISBN 10: 6200539138
• ISBN 13: 9786200539137
• Binding: Soft cover
• Condition: New

About this title

Synopsis

To obtain an enhanced in-vitro dissolution rate of simvastatin by using Liquisolid technique and Liquisolid tablets were optimized by DoE approach 32 full factorial design using Design Expert Software.The liquisolid tablets were formulated by using propylene glycol (PG), as liquid vehicle, Avicel PH-102 as a carrier material, Aerosil as a coating material, and aspartame as sweetener and Kyron 314 as a superdisintegrant. The new mathematical model 32 full factorial design was utilized to formulate various liquisolid powder systems and to calculate amount of carrier material and coating material.Simvasatin Liquisolid compacts enhance aqueous solubility and dissolution rate in compare to other solubility enhancement technique. Hence, this research work may be useful to formulate fast disintegrating Tablets using Liquisolid Technique which may give rapid onset of action by rapid absorption, maximize efficacy, reduce dose and dose frequency & hence increase patient Compliance.