Fenoprofen Calcium Compressed Coated Tablets for Colon Drug Delivery : Fenoprofen Calcium Compressed Coated Tablets

Apparao Potu

ISBN 10: 3848497026 / ISBN 13: 9783848497027

Published by LAP Lambert Academic Publishing, 2012

About this Item

nach der Bestellung gedruckt Neuware - Printed after ordering - The aim of this study was to design and evaluate a colon targeting delivery for fenoprofen calcium with better benefits in treating the arthritis. Compression coated tablets were prepared by using guar gum as a coating material over core tablets. These systems would benefit for the high amount release of the drug in the distal intestinal or the colon, this may exhibit better fenoprofen calcium toward the arthritis by reduce the serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the stomach, small intestine or large intestine. Plan of work: 1) Formulation of fenoprofen calcium core tablets by direct compression. 2) Compression coating over the fenoprofen calcium core tablets using guar gum as a coating material. 3) Optimization of the coat thickness as the minimum that can provide protection against the gastric and intestinal environment. 4) Characterization of prepared powder mixer Angle of repose Bulk density Tapped density Carr s index(compressibility index) 5) Characterization of core and compression coated tablets for following parameters Weight variation Tablet thickness Tablet hardness Friabil.

Seller Inventory # 9783848497027

Bibliographic Details

• Title: Fenoprofen Calcium Compressed Coated Tablets for Colon Drug Delivery : Fenoprofen Calcium Compressed Coated Tablets
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3848497026
• ISBN 13: 9783848497027
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 176H x 33D millimeters 220 millimeters width by 176 millimeters height by 33 millimeters depth
• Weight: 153 grams

About this title

Synopsis

The aim of this study was to design and evaluate a colon targeting delivery for fenoprofen calcium with better benefits in treating the arthritis. Compression coated tablets were prepared by using guar gum as a coating material over core tablets. These systems would benefit for the high amount release of the drug in the distal intestinal or the colon, this may exhibit better fenoprofen calcium toward the arthritis by reduce the serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the stomach, small intestine or large intestine. Plan of work: 1) Formulation of fenoprofen calcium core tablets by direct compression. 2) Compression coating over the fenoprofen calcium core tablets using guar gum as a coating material. 3) Optimization of the coat thickness as the minimum that can provide protection against the gastric and intestinal environment. 4) Characterization of prepared powder mixer  Angle of repose  Bulk density  Tapped density  Carr's index(compressibility index) 5) Characterization of core and compression coated tablets for following parameters  Weight variation  Tablet thickness  Tablet hardness  Friabil

About the Author

I Apparao Potu, Professor in Pharmacy, 24 years teaching experience, conducted several research and published in international journals, find out the manuscript and do needful.Thank you