Fenoprofen Calcium Compressed Coated Tablets for Colon Drug Delivery | Fenoprofen Calcium Compressed Coated Tablets

Apparao Potu (u. a.)

ISBN 10: 3848497026 ISBN 13: 9783848497027

Published by LAP Lambert Academic Publishing, 2012

Language: English

Condition: New Soft cover

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Bibliographic Details

Title

Fenoprofen Calcium Compressed Coated Tablets for Colon Drug Delivery | Fenoprofen Calcium Compressed Coated Tablets

Publisher

LAP Lambert Academic Publishing

Publication Date

2012

Language

English

ISBN 10

3848497026

ISBN 13

9783848497027

Binding

Taschenbuch

Condition

Neu

Seller catalogs

B�cher

About this title

Synopsis

The aim of this study was to design and evaluate a colon targeting delivery for fenoprofen calcium with better benefits in treating the arthritis. Compression coated tablets were prepared by using guar gum as a coating material over core tablets. These systems would benefit for the high amount release of the drug in the distal intestinal or the colon, this may exhibit better fenoprofen calcium toward the arthritis by reduce the serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the stomach, small intestine or large intestine. Plan of work: 1) Formulation of fenoprofen calcium core tablets by direct compression. 2) Compression coating over the fenoprofen calcium core tablets using guar gum as a coating material. 3) Optimization of the coat thickness as the minimum that can provide protection against the gastric and intestinal environment. 4) Characterization of prepared powder mixer  Angle of repose  Bulk density  Tapped density  Carr's index(compressibility index) 5) Characterization of core and compression coated tablets for following parameters  Weight variation  Tablet thickness  Tablet hardness  Friabil

About the Author

I Apparao Potu, Professor in Pharmacy, 24 years teaching experience, conducted several research and published in international journals, find out the manuscript and do needful.Thank you

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