Floating Strategie & Low Absorption Drug | Needs of Floating Drug Delivery System

Aslam Siddiqui (u. a.)

ISBN 10: 3659117935 / ISBN 13: 9783659117930

Published by LAP Lambert Academic Publishing, 2012

About this Item

Floating Strategie & Low Absorption Drug | Needs of Floating Drug Delivery System | Aslam Siddiqui (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659117930 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

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Bibliographic Details

• Title: Floating Strategie & Low Absorption Drug | Needs of Floating Drug Delivery System
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659117935
• ISBN 13: 9783659117930
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

Floating Drug Delivery Systems have emerged as an efficient means of enhancing the bioavailability and controlled delivery of Diltiazem hydrochloride. Drug absorption in the gastrointestinal tract is a highly variable processes and prolonging the gastric retention of dosage form via floating drug delivery system extends the time for drug absorption and ultimately increase bioavailability of drug. Diltiazem hydrochloride is a benzothiazepine-derivative calcium-channel blocker was chosen as a model drug due to its low oral bioavailability (30-40 %), short half-life (3 to 4 hrs), High frequency of dosing and low solubility at lower part of GI tract which makes it an appropriate candidate for a formulation in a sustained release floating drug delivery system, twice-a-day dosage form. The present study was aimed at designing a effervescent floating tablet of Diltiazem hydrochloride for controlled release of Diltiazem using different grades of Hydroxy propyl methyl cellulose such as HPMC K4M, HPMC K15M, HPMC K100M and Xanthan gum to achieve improved economy of tablet. Sodium bicarbonate and citric acid was used as a gas generating agent.

About the Author

Asst.Professor Aslam Siddiqui has obtained his Master Degree in Pharmaceutics in 2010. Since then he has worked on different research topics in the field of novel drug delivery system. He is also the author of different research articles published in reputed journals and is a member of Association of Pharmaceutical Teachers of India.