Formulation and Characterization of Aceclofenac Microsphere: Aceclofenac Microsphere

Verma, Sofiya, Chaurasia, Sandhya, Asati, Ashok

ISBN 10: 3659202320 / ISBN 13: 9783659202322

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Formulation and Characterization of Aceclofenac Microsphere: Aceclofenac Microsphere
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659202320
• ISBN 13: 9783659202322
• Binding: paperback
• Condition: New
• Book Type: book

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Synopsis

The purpose of this research was to prepare and characterize Aceclofenac microsphere of guar gum polymer for the application of inflammation. Method: - The microsphere were prepared by using emulsification method using starch cross-linked agent and coating was done by solvent evaporation method with the pH sensitive eudragit S-100 polymers. Result:-The prepared microsphere were white, free flowing and spherical in shape. The drug-loaded microsphere showed entrapment efficiency and drug release was extended upto 6 to 8 h. The infrared spectra, differential scanning calorimetry thermographs spectra all showed the stable character of both the drugs in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The stability study was conducted to conform the stability of prepared microsphere. In-vitro drug release study was performed in both simulated gastrointestinal fluid medium and rat cecal content of different pH. Conclusion:-The prepared Aceclofenac microsphere has the potential for delaying the release of drug.

About the Author

Sofiya Verma completed her M Pharmacy fromRajiv Gandhi Technical University Bhopal M.P.(India)Sofiya Verma having excellent academicsrecord. She is currently working as Asst. Professor at daksh institute of pharmaceutical science chhatarpur (M.P)