Formulation and Characterization of Ranitidine Hydrochloride: Mucoadhesive Drug Delivery System

Ashok Asati, Sofiya Verma, Sandhya Chaurasia

ISBN 10: 3659195677 / ISBN 13: 9783659195679

Published by LAP LAMBERT Academic Publishing 2012-07-24, 2012

About this Item

Seller Inventory # 6666-IUK-9783659195679

Bibliographic Details

• Title: Formulation and Characterization of Ranitidine Hydrochloride: Mucoadhesive Drug Delivery System
• Publisher: LAP LAMBERT Academic Publishing 2012-07-24
• Publication Date: 2012
• Language: English
• ISBN 10: 3659195677
• ISBN 13: 9783659195679
• Binding: Paperback
• Condition: New

About this title

Synopsis

prepare and evaluate mucoadhesive drug delivery system of Ranitidine hydrochloride tablet using hydrophilic polymers in order to reduce dose frequency to match the initial release of the drug with the conventional dosage form. The formulation was designed adopting optimization technique, which helps in setting up experiments in such a manner that the information is obtained as efficiently and precisely as possible. Initially, considering buoyancy as the main criteria, blank tablets were compressed for different formulae with various polymers HPMC K 15 M, HPMC K 100 M, Carbopol 934. The tablets were prepared by direct compression method and evaluated for Ranitdine content, in vitro release profile and buoyancy. The dissolution study was carried out in simulated gastric fluid using USP dissolution test apparatus employing paddle stirrer.. This indicates the suitability of the technique chosen for the present dosage form.

About the Author

Ashok Asati completed his M Pharmacy from Singhania University Jhujhunu Rajasthan(India. Ashok Asati having excellent academics record. He is currently working as Asst. Professor at daksh institute of pharmaceutical science chhatarpur (M.P)