Formulation and Development of Bilayer Floating Tablets of Nifedipine | Formulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique

Dinesh Kumar Sharma (u. a.)

ISBN 10: 620341087X / ISBN 13: 9786203410877

Published by LAP LAMBERT Academic Publishing, 2021

About this Item

Formulation and Development of Bilayer Floating Tablets of Nifedipine | Formulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique | Dinesh Kumar Sharma (u. a.) | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2021 | LAP LAMBERT Academic Publishing | EAN 9786203410877 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 119729811

Bibliographic Details

• Title: Formulation and Development of Bilayer Floating Tablets of Nifedipine | Formulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2021
• Language: English
• ISBN 10: 620341087X
• ISBN 13: 9786203410877
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 8D millimeters 220 millimeters width by 150 millimeters height by 8 millimeters depth
• Weight: 179 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.