Formulation and Development of Cefixime Trihydrate Floating Tablets | Cefixime trihydrate floating tablets for the treatment of peptic ulcer

Binapani Barik

ISBN 10: 6203196134 / ISBN 13: 9786203196139

Published by LAP LAMBERT Academic Publishing, 2020

About this Item

Formulation and Development of Cefixime Trihydrate Floating Tablets | Cefixime trihydrate floating tablets for the treatment of peptic ulcer | Binapani Barik | Taschenbuch | Englisch | 2020 | LAP LAMBERT Academic Publishing | EAN 9786203196139 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 119526932

Bibliographic Details

• Title: Formulation and Development of Cefixime Trihydrate Floating Tablets | Cefixime trihydrate floating tablets for the treatment of peptic ulcer
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2020
• Language: English
• ISBN 10: 6203196134
• ISBN 13: 9786203196139
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 7D millimeters 220 millimeters width by 150 millimeters height by 7 millimeters depth
• Weight: 173 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

The purpose of this research is to develop the hydro-dynamically balanced delivery system of Cefixime Trihydrate for the localized action in the stomach, in the treatment of H.pylori mediated peptic ulcer. By applying wet granulation technique floating tablets of cefixime trihydra is prepare. Drug-Excipient compatibility study is performed by FTIR and DSC .Eudragit RS 100 polymer is use for maintaining drug release, % drug release, floating lag time and swelling index. The formulation developed using Cefixime trihydrate, Eudragit RS100, sodium bicarbonate gave floating lag time with a floating time of 12 h, and an in vitro release profile very near to the desired release. In vivo radiographic studies performed with Barium sulphate loaded formulation suggest that the tablet increase gastric residence time for the effective localized action of the antibiotic (Cefixime trihydrate) in the treatment of peptic ulcer.