Formulation Development and Evaluation: Of Antifungal Proniosomal Gel for Topical Application

Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of traditional drug delivery systems and are able to deliver drug at the site of action and at predetermined rate which increases therapeutic efficacy, minimize adverse or side effects and increases bioavailability of the drug. Drug delivery system using colloidal particulate carriers such as liposomes and niosomes have distinct advantages over conventional dosage forms i.e. shows strong potential for effective drug delivery to the site of action, biologically inert in nature, release the drug in sustained and controlled manner and also have ability to entrap both hydrophilic and lipophilic drugs. However, remain significant problems like instability in general application of liposomes and niosomes for drug delivery. To overcome these problems, Provesicular concept has evolved to resolve the stability issues pertaining to conventional vesicular systems. These proniosomes minimize problems of niosomes physical stability such as aggregation, fusion, leakage of drug from formulation and provide additional convenience in transportation, distribution, storage and dosing.