Formulation, Development & Evaluation of Multi-compartment Dosage Form | For Immediate Relief From Hypertension

Naisarg Pujara (u. a.)

ISBN 10: 3659410470 / ISBN 13: 9783659410475

Published by LAP LAMBERT Academic Publishing, 2013

About this Item

Formulation, Development & Evaluation of Multi-compartment Dosage Form | For Immediate Relief From Hypertension | Naisarg Pujara (u. a.) | Taschenbuch | 188 S. | Englisch | 2013 | LAP LAMBERT Academic Publishing | EAN 9783659410475 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 105901266

Bibliographic Details

• Title: Formulation, Development & Evaluation of Multi-compartment Dosage Form | For Immediate Relief From Hypertension
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2013
• Language: English
• ISBN 10: 3659410470
• ISBN 13: 9783659410475
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 12D millimeters 220 millimeters width by 150 millimeters height by 12 millimeters depth
• Weight: 298 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

In the present study, formulation of multi-compartment dosage form containing soft gelatin capsule of Nifedipine, granules of Losartan potassium and fast disintegrating tablet of Hydrochlorothiazide was designed to achieve immediate release of drug from the dosage form, to increase therapeutic efficacy and to improve patient compliance in case of hypertension. Triple combination of antihypertensive drugs induces superior reduction in blood pressure as compared to conventional dosage form. The basic aim of this work is to produce immediate release action of drug from the hard gelatin capsule containing soft gelatin capsule of Nifedipine, granules of Losartan potassium and fast disintegrating tablet of Hydrochlorothiazide. Soft gelatin capsule was prepared by encapsulation method using propylene glycol and PEG 400 as solubilizing agents. The granules were prepared by wet granulation method using PVP K30 as binder. The fast disintegrating tablets were prepared by direct compression method using croscarmellose sodium and crospovidone as super disintegrating agents. Multi-compartment dosage form was considered as optimized formulation for immediate release of antihypertensive drugs.

About the Author

Naisarg D. Pujara, Master of Pharmacy, Pharmaceutics at Gujarat Technological University. Pharmacy Scholar at S. J. Thakkar Pharmacy College, Rajkot, Gujarat, India. Published Five International Books, Seven National & International Research articles and Five National & International Review articles. Reviewer of Two Elsevier Journals.