Formulation and Development of Triamcinolone Acetonide Loaded Nanosponges: Its Potential Topical Application

The ideal of the exploration is to formulate hydrogel containing nanosponges of Triamcinolone acetonide for the treatment of Psoriasis. Psoriasis is presently treated with a numerous of topical and systemic remedies. Numerous of these treatments, still, are costly and involve adverse effects, similar as immunosuppression. As a result, there is a need to develop curatives that are effective, have less adverse effects, and are less costly. With the use of solvent emulsion diffusion process triamcinolone acetonide nanosponges were formulated, in which Eudragit L-100 was used as polymer, polyvinyl alcohol was used as an emulsifying agent, and an organic solvent mixture of Dichloromethane was used to make nanosponges. For the preparation of optimized batches of Hydrogel containing nanosponges various gelling agents were used such as Carbopol 934, HPMC K4, Sodium alginate and Acacia with same concentration. Therefore, with the help of different analytical tests i.e., SEM, FT-IR, Zeta potential etc. It was confirmed that by using the nanosponges formulation the biopharmaceutical characteristics of triamcinolone acetonide increased which is a BCS Class IV drug.