Formulation And Evaluation Of Cinnarizine Floating Tablets : A Floating Type Approach of Gastro - retentive Tablet Dosage Form of Cinnarizine, An Anti Histaminic Drug

Language: English

Published by LAP Lambert Academic Publishing, 2012

3659240974 / 9783659240973

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Cinnarizine, a piperazine derivative with anti-histaminic activity finds its major use in control of vomiting due to motion sickness. It has a short half-life of 3-6 hrs. & the usual dosage regimen is 75 mg twice or three times a day for adults. The floating tablets of cinnarizine were formulated using varying concentration of HPMC K4M & effervescent agents by wet granulation technique. The granules were evaluated for angle of repose, bulk density, tapped density, Carr s index, Hausner s ratio & drug content. The tablets were evaluated for thickness, hardness, weight variation test, friability, in vitro buoyancy & in vitro dissolution study. A 3 Square factorial design was used to study the effect of HPMC K4M & citric acid on lag time, floating time & percentage cumulative release. The responses were analyzed using ANOVA & by the predictive equation, it was found that the concentration of HPMC K4M & citric acid significantly affected all the response parameters. The obtained model was validated & optimized formulation was prepared as suggested by the software. All the predicted values of responses were found to be closed to the observed values.…

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Title
Formulation And Evaluation Of Cinnarizine Floating Tablets : A Floating Type Approach of Gastro - retentive Tablet Dosage Form of Cinnarizine, An Anti Histaminic Drug
Author
Sumit Doshi
Publisher
LAP Lambert Academic Publishing
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659240974
ISBN 13
9783659240973
Item weight
231 grams
Dimensions
220x150x33 mm

AHA-BUCH GmbH

Einbeck, Germany

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