Formulation And Evaluation Of Cinnarizine Floating Tablets: A Floating Type Approach of Gastro - retentive Tablet Dosage Form of Cinnarizine, An Anti Histaminic Drug

Sumit Doshi

ISBN 10: 3659240974 / ISBN 13: 9783659240973

Published by LAP LAMBERT Academic Publishing, 2012

About this Item

144 pages. 8.66x5.91x0.33 inches. In Stock.

Seller Inventory # 3659240974

Bibliographic Details

• Title: Formulation And Evaluation Of Cinnarizine Floating Tablets: A Floating Type Approach of Gastro - retentive Tablet Dosage Form of Cinnarizine, An Anti Histaminic Drug
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659240974
• ISBN 13: 9783659240973
• Binding: Paperback
• Condition: Brand New
• Weight: 0.26 kilograms

About this title

Synopsis

Cinnarizine, a piperazine derivative with anti-histaminic activity finds its major use in control of vomiting due to motion sickness. It has a short half-life of 3-6 hrs. & the usual dosage regimen is 75 mg twice or three times a day for adults. The floating tablets of cinnarizine were formulated using varying concentration of HPMC K4M & effervescent agents by wet granulation technique. The granules were evaluated for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio & drug content. The tablets were evaluated for thickness, hardness, weight variation test, friability, in vitro buoyancy & in vitro dissolution study. A 3 Square factorial design was used to study the effect of HPMC K4M & citric acid on lag time, floating time & percentage cumulative release. The responses were analyzed using ANOVA & by the predictive equation, it was found that the concentration of HPMC K4M & citric acid significantly affected all the response parameters. The obtained model was validated & optimized formulation was prepared as suggested by the software. All the predicted values of responses were found to be closed to the observed values.

About the Author

Bachelor of Pharmacy from J. S. S. College of Pharmacy, Ooty. Master of Pharmacy in Pharmaceutical Technology from Rajiv Gandhi University of Health Sciences, Karnataka. Pursuing Ph D from R. K. University, Rajkot. Attended 6 National Conferences & Presented 4 Posters at National Level. Published 4 International Publications in Reputed Journals.