Formulation and Evaluation of Fast Dissolving Film of Chlorpromazine : Fast Dissolving Film of Chlorpromazine

Language: English

Published by LAP LAMBERT Academic Publishing, 2020

6202524200 / 9786202524209

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Emesis is the involuntary and forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. Receptors on the floor of the ventricle of the brain represent a chemo-receptor trigger zone, known as the area postrema, stimulation of which can lead to vomiting. Chlorpromazine HCl is formulated as a sublingual film. The films formed by HPMC K-15 at a concentration of 120 mg showed the desirable character for a sublingual film. The optimized films formed were subjected to evaluation parameters viz. Tensile Strength, Disintegration, In-vitro dissolution, Ex-vivo Permeation studies and In-vivo studies and the results complied with the available statistical data. In-vitro dissolution studies were analyzed and Higuchi model was found to be the best fit model for In-vitro dissolution studies with a regression value of 0.9248. Ex-vivo permeation studies showed fivefold enhanced permeation of drug from films as compared to pure drug. In conclusion, a sublingual film of Chlorpromazine HCl may result in better patient compliance, quick onset of action and enhanced bio-availability.…

Seller Inventory # 9786202524209

Title
Formulation and Evaluation of Fast Dissolving Film of Chlorpromazine : Fast Dissolving Film of Chlorpromazine
Author
Vinay Pandit
Publisher
LAP LAMBERT Academic Publishing
Publication year
2020
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6202524200
ISBN 13
9786202524209
Item weight
191 grams
Dimensions
220x150x8 mm

AHA-BUCH GmbH

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