Formulation & Evaluation Of Floating Matrix Tablets Of Levofloxacin: Gastro - Retentive Floating Matrix Tablets

Dudhipala, Narendar; Reddy, Sunil; Yamsani, Madhusudan Rao; Dudhipala, Narendar; Reddy, Sunil; Yamsani, Madhusudan Rao

ISBN 10: 3659238147 / ISBN 13: 9783659238147

Published by Lap Lambert Academic Publishing, 2012

About this Item

64 pages. 8.82x6.18x0.39 inches. In Stock.

Seller Inventory # zk3659238147

Bibliographic Details

• Title: Formulation & Evaluation Of Floating Matrix Tablets Of Levofloxacin: Gastro - Retentive Floating Matrix Tablets
• Publisher: Lap Lambert Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659238147
• ISBN 13: 9783659238147
• Binding: Paperback
• Condition: Brand New
• Weight: 0.14 kilograms

About this title

Synopsis

The purpose of this investigation was to design and develop gastroretentive dosage form for levofloxacin hemihydrate using floating tablet approach with various grades of hydroxypropyl methyl cellulose. Levofloxacin highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastro retentive system was developed to enhance the bioavailability and therapeutic efficacy by retaining them in the acidic environment of the stomach. Sodium bicarbonate was used in the dosage form as a source of carbon-di-oxide to maintain buoyancy. In vitro dissolution study results indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into zero-order equation. In vivo radiographic studies conducted in healthy human volunteers for optimized formulation indicated over 5 h retention of tablet in the stomach region. Reproducible physical parameters indicated that the current formulation could be easily scaled-up.

About the Author

Mr. Narendar Reddy Dudhipala, presently Research Scholar under the supervision of Prof. V. Kishan in the Department of Pharmaceutics at University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AndraPradesh, India. He completed His B.Pharm and M.Pharm from Kakatiya University. He received “Research Excellence awrad” in 63rd IPC.