Formulation and Evaluation of Ion Exchange Resin Based Soluble Ocusert: Ocular Insert of Moxifloxacin Hydrochloride: A Novel Approach for Controlled Drug Delivery System

Parmar, Ramesh, Tank, H. M.

ISBN 10: 3843363374 / ISBN 13: 9783843363372

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Formulation and Evaluation of Ion Exchange Resin Based Soluble Ocusert: Ocular Insert of Moxifloxacin Hydrochloride: A Novel Approach for Controlled Drug Delivery System
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3843363374
• ISBN 13: 9783843363372
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

In recent years scientific and technological advances have been made in development of ocular controlled drug delivery system to overcome physiological adversities of conventional dosage form. The present investigation was focused to prepare resinate of moxifloxacin and ion exchange resign to increase the residence time and decrease the solubility of drug in ocular site and incorporated in ocular insert. Ocular insert was prepared by solvent casting method. Nine formulations of OCDDS were prepared with different concentration of polymer (HPMC, MC, and PVA). Prepared formulation was subjected to physicochemical evaluation test,In vitro release, In vivo release and accelerated stability study test. In vivo release of formulation BRF6 was shown 98.87 % at the end of 12th hrs. In vitro release of all the formulation was computed with release kinetic model to predict release rate.suggested that all formulation was followed anomalous diffusion mechanism. Optimized formulation (BRF6) was subjected to antimicrobial test and sterility test. Result clearly showed it was passed. Accelerated stability study indicated optimized formulation was stable for longer period of time.

About the Author

Ramesh B. Parmar, Assistant Professor and Head of Pharmaceutics Department at S. J. Thakkar Pharmacy College, Rajkot. Completed my Ph. D. Work under the Guidance of Dr. H. M. Tank from Saurashtra University. I have Presented 6 international Poster and published 15 national & international research paper. I have Guided 18 M. Pharm. Students.