Formulation and Evaluation of Mucoadhesive Drug Delivery Systems | A Novel Approach to Overcome First-Pass Metabolism of Salbutamol Sulphate via Mucoadhesive Buccal Tablets

Publisher

LAP LAMBERT Academic Publishing

Publication Date

2026

Language

English

ISBN 10

620960692X

ISBN 13

9786209606922

Binding

Taschenbuch

Condition

Neu

Dimensions

Weight

203 grams

Seller catalogs

B�cher

About this title

Synopsis

Buccal drug delivery bypasses hepatic first-pass metabolism, offering improved bioavailability over conventional oral administration. This work presents the formulation and evaluation of mucoadhesive buccal tablets of Salbutamol sulphate using natural polymers-Xanthan gum, Guar gum, and Sodium alginate.FTIR and DSC studies confirmed drug-excipient compatibility. Thirty formulations prepared by direct compression, with Ethyl cellulose as a backing layer, met all standard physicochemical parameters. In-vitro dissolution showed up to 100.81% drug release over 8 hours following zero-order kinetics. In-vivo studies on rabbits confirmed 87.37% buccal absorption with sustained plasma levels and higher AUC than oral administration. Good in-vitro/in-vivo correlation and three-month stability were demonstrated.These results establish mucoadhesive buccal tablets as an effective, stable, and bioavailable dosage form for asthma management.

"About this title" may belong to another edition of this title.

Store Description

preigu betreibt einen Onlineversandhandel mit �ber 1 Mio. Produkten in verschiedenen Sortimenten. Das Kernsortiment besteht aus B�chern, Medien und Spielwaren. Ein gelungenes Einkaufserlebnis ist das Ziel einer jeden Bestellung bei preigu, denn der Kunde und seine Zufriedenheit stehen an erster Stelle. preigu setzt daher auf einen kompetenten Kundenservice, funktionierende Prozesse und schnelle Reaktion.

Visit Seller's Storefront

Seller's business information

preigu GmbH & Co. KG
Lengericher Landstra�e 19, Osnabr�ck, 49078, Germany

Sale & Shipping Terms

Terms of Sale

Standard Business Terms and customer information / data protection declaration / battery disposal

I. Standard business terms

� 1 Basic provisions

(1) The following terms and conditions of business apply for all contracts concluded with us as the supplier (preigu GmbH & Co. KG) via the websites AbeBooks and/or ZVAB. Unless otherwise agreed, the inclusion of your own terms and conditions is explicitly rejected.

(2) A ?consumer' in the sense of the following regulations is every natural person who ...

More Information

Shipping Terms

Shipping rates from Germany to U.S.A.

Shipping rates from Germany to U.S.A.
Order quantity	60 to 60 business days	60 to 60 business days
First item	US$ 81.30	US$ 81.30

Delivery times are set by sellers and vary by carrier and location. Orders passing through Customs may face delays and buyers are responsible for any associated duties or fees. Sellers may contact you regarding additional charges to cover any increased costs to ship your items.