Formulation and Evaluation of Sustained release tablets of Tizanidine

Language: English

Published by LAP LAMBERT Academic Publishing Feb 2017, 2017

3330051566 / 9783330051560

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This item is printed on demand - Print on Demand Titel. Neuware -The objective of this study is to formulate and evaluate the sustained release matrix tablet of Tizanidine Hydrochloride by direct compression method. In the present study, Tizanidine is chosen as a model drug which is Muscle relaxant. Because of its short half life (2.5hrs), its water solubility and less bioavailability (40%) it was chosen as a suitable candidate for sustain matrix tablet formulation. It was formulated in to matrix tablet using polymer such as iota-Carrageenan and Polyethylene oxide as releases retardants. All the pre-compression parameters, post-compression parameters were found to be within the standard IP limits. Matrix tablet with Carrageenan and Polyethylene oxide successfully sustained the release of Tizanidine for a period of 12hrs. The concentration of tizanidine was kept constant, MCC-101 and lactose (1:3 ratio) used as filler. The maximum in-vitro release (at 50rpm, temperature 37±0.5°C, and 0.1N HCl, pH 6.8 phosphate buffers) was found to be 97.8% and 98.6% over a period of 12hrs for formulations C4 and P4. The data of in-vitro release from tablets were fitted to different kinetic models to explain the release profile. Formulations C4 and P4 were bestVDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 104 pp. Englisch.…

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Title
Formulation and Evaluation of Sustained release tablets of Tizanidine
Author
Venkata Raghava Reddy P.
Publisher
LAP LAMBERT Academic Publishing Feb 2017
Publication year
2017
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3330051566
ISBN 13
9783330051560
Item weight
173 grams
Dimensions
220x150x7 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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