Formulation & evaluation of delayed release anti depressant capsule

Language: English

Published by LAP LAMBERT Academic Publishing Apr 2015, 2015

3659693898 / 9783659693892

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This item is printed on demand - Print on Demand Titel. Neuware -The aim of work entitled 'To Develop a Delayed release Capsule Formulation of Antidepressant Drug' was to formulate a stable as well as robust dosage form. The basic objective was to develop a Delayed Release Formulation of Antidepressant Drug. It is a generic version of Antidepressant capsules in line with the innovator. A generic version of Capsule was developed that is safe, efficacious and bioequivalent to the reference product. The compatibility parameters characterization of Antidepressant drug and excipients were done by chemical method and found interaction between Antidepressant drug and free acid present in enteric polymers hydroxypropyl methylcellulose phthalate, which forms phthalamide impurities under stress conditions .So the enteric layer must be separated from the drug layer by a barrier layer.The Antidepressant Drug was evaluated for bulk density, tapped density, Carr's index and Hausner's Ratio. It was found that the drug has good flow properties.The formulation of Delayed release pellets was done in Fluidized bed Processor(GPCG 1.1) in 3 steps. 1. Drug layering on Sugar spheres. 2. Barrier Coating on drug layered pellets. 3. Enteric Coating on pellets.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 96 pp. Englisch.…

Seller Inventory # 9783659693892

Title
Formulation & evaluation of delayed release anti depressant capsule
Author
Yogesh Kumar Garg
Publisher
LAP LAMBERT Academic Publishing Apr 2015
Publication year
2015
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659693898
ISBN 13
9783659693892
Item weight
161 grams
Dimensions
220x150x7 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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