Formulation and evaluation of ternary dispersion of curcumin: A boon to herbal medicine

GUPTA, ARUN, KUMAR, ARVIND, Kamboj, Rajwinder

ISBN 10: 3659548197 / ISBN 13: 9783659548192

Published by LAP LAMBERT Academic Publishing, 2014

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Bibliographic Details

• Title: Formulation and evaluation of ternary dispersion of curcumin: A boon to herbal medicine
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2014
• Language: English
• ISBN 10: 3659548197
• ISBN 13: 9783659548192
• Binding: paperback
• Condition: New
• Book Type: book

About this title

Synopsis

Curcumin is a yellow-orange powder that is insoluble in water and ether but soluble in ethanol, dimethylsulfoxide, and acetone. Curcuminoids exhibit a broad spectrum of biological and pharmacological activities. Curcumin's unique ability to work through so many different pathways with its extraordinary antioxidant and anti-inflammatory attributes can have a positive influence in combating almost every known disease. In spite of high efficacy and safety, curcumin has not yet been approved as a therapeutic agent, due to the poor solubility and oral bioavailability. Aim of this work is to formulate and evaluate the ternary dispersion (Third Generation Solid Dispersion) of curcumin in order to enhance the dissolution rate by solvent evaporation method (coprecipitation method) with the use of Carrier & Poloxamer. Ternary solid dispersions avoid the drug recrystallization and thus enhance the dissolution rate than Binary solid dispersion.A ternary solid dispersion with solvent evaporation method (coprecipitation method) meets the above requirement to prepare the highly soluble curcumin preparation and comparatively cheaper product ever before.

About the Author

Arun Gupta is presently working as Asst. Professor in S.D.College of pharmacy & Vocational studies, U.P., India. He has also been associated with the different types of research work in the field of pharmaceutics.