Formulation and process variables influencing nanoparticles properties: Factors influencing properties of nanoparticles prepared by nanoprecipitation and emulsification-based methods

Simonoska Crcarevska, Maja/ Glavas Dodov, Marija/ Lazarevski, Nikola

ISBN 10: 6202077662 / ISBN 13: 9786202077668

Published by LAP LAMBERT Academic Publishing, 2017

About this Item

120 pages. 8.66x5.91x0.28 inches. In Stock.

Seller Inventory # zk6202077662

Bibliographic Details

• Title: Formulation and process variables influencing nanoparticles properties: Factors influencing properties of nanoparticles prepared by nanoprecipitation and emulsification-based methods
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2017
• Language: English
• ISBN 10: 6202077662
• ISBN 13: 9786202077668
• Binding: Paperback
• Condition: Brand New
• Weight: 0.23 kilograms

About this title

Synopsis

Having in mind the toxicity of certain drugs, problems associated with multi drug resistance and favorable pharmacokinetic properties offered by nanoparticulated drug delivery systems (NDDS), it could be said that nanoencapsulation is a challengeable and interesting approach to achieve desired benefits of lower toxicity and increased drug accumulation into the target tissue/organ. The first step that needs to be mastered in the NDDS design, is to achieve prolonged blood circulation time by providing the adequate nanoparticle (NP) size (<200 nm), surface charge (preferably neutral), shape and surface properties (preferably hydrophilic) as basic requirements for circumvention of mononuclear phagocyte system and desired NDDS accumulation into the targeted tissue. So, when optimizing NP formulations in order to achieve the desired characteristics in vivo, it is of high importance to consider the various preparation, formulation and process factors that can influence the NP size, zeta potential, encapsulation efficiency and drug dissolution, among other properties. This review gives an overview of most studied factors influencing NDDS physicochemical and biopharmaceutical properties.

About the Author

Maja Simonoska Crcarevska is ass. prof. at Faculty of pharmacy, Ss. Cyril and Methodius University in Skopje, R. Macedonia. Marija Glavas Dodov is asoc. prof. at the same Faculty. Nikola Lazarevski works in PharmInvent, Czech Republic. Authors have high expertise in the field of design, development & formulation of advanced drug delivery systems.