Fragment Based Drug Design

ISBN 10: 0123812747 / ISBN 13: 9780123812742

Published by Elsevier, 2011

About this Item

pp. 645.

Seller Inventory # 5529051

Bibliographic Details

• Title: Fragment Based Drug Design
• Publisher: Elsevier
• Publication Date: 2011
• Language: English
• ISBN 10: 0123812747
• ISBN 13: 9780123812742
• Binding: Hardcover
• Condition: New

About this title

Synopsis

There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits.

• Offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens
• The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD