Fragment-Based Drug Discovery: A Practical Approach
Language: English
Published by Wiley, 2008
- Hardcover
- Used
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- Title
- Fragment-Based Drug Discovery: A Practical Approach
- Publisher
- Wiley
- Publication year
- 2008
- Condition
- Good
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 0470058137
- ISBN 13
- 9780470058138
Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include:
- an introduction to fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort.
- setting up an FBDD project
- library building and production
- NMR in fragment screening and follow up
- application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses
- target immobilized NMR screening: validation and extension to membrane proteins
- in situ fragment-based medicinal chemistry: screening by mass spectrometry
- computational approaches to fragment and substructure discovery and evaluation
- virtual fragment scanning: current trends, applications and web based tools
- fragment-based lead discovery using covalent capture methods
- case study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generation
With contributions from industry experts who have successfully set up an industrial fragment-based research program, Fragment-Based Drug Discovery: A Practical Approach offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.
"Synopsis" may belong to another edition of this title.
About the Author
Edward R. Zartler, Strategy Consultant, Eli Lilly & Co.; Established the Fragment-based Drug Design paradigm at Eli Lilly.
Michael J. Shapiro, Associate Professor of Pharmacy, University of Maryland School of Pharmaceutical Sciences; Industry experience at Lilley, Novartis and Sandoz.
"About the title" may belong to another edition of this title.
Phatpocket Limited
Waltham Abbey, HERTS, United Kingdom
AbeBooks seller since April 28, 2005
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