Fragment-Based Methods in Drug Discovery

Language: English

Published by Humana Okt 2016, 2016

1493946145 / 9781493946143

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This item is printed on demand - Print on Demand Titel. Neuware -This volume covers the techniques necessary for a successful fragment-based drug design project, beginning from defining the problem in terms of preparing the protein model, identifying potential binding sites, and the consideration of various candidate fragments for simulation. The second part discusses the technical aspects that various methods have used to simulate fragment binding to a target protein by using Monte Carlo, molecular dynamics, and docking algorithms. After simulations, fragments are assembled into molecules using a variety of approaches, which are explored next. A discussion of design strategies and consideration of drug-like properties is included as part of the design process at this stage. Finally, several examples of successful fragment-based drug design projects are presented. Written for the Methods in Molecular Biology series, this work contains the kind of detailed description and implementation advice to encourage success in the lab.Practical and cutting-edge, Fragment-Based Methodsin Drug Discovery takes into account the great accomplishments in the field to provide an ideal guide for researchers continuing to investigate this exciting area of pharmacological study.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 240 pp. Englisch.…

Seller Inventory # 9781493946143

Title
Fragment-Based Methods in Drug Discovery
Author
Anthony E. Klon
Publisher
Humana Okt 2016
Publication year
2016
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
1493946145
ISBN 13
9781493946143
Item weight
514 grams
Dimensions
254x178x13 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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