Functional Selectivity of G Protein-Coupled Receptor Ligands

Language: English

Published by Humana Aug 2016, 2016

1493961160 / 9781493961160

Series: Book 5 of 29 - The Receptors

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This item is printed on demand - Print on Demand Titel. Neuware -Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 304 pp. Englisch.

Seller Inventory # 9781493961160

Title
Functional Selectivity of G Protein-Coupled Receptor Ligands
Author
Kim Neve
Publisher
Humana Aug 2016
Publication year
2016
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
1493961160
ISBN 13
9781493961160
Item weight
464 grams
Dimensions
235x155x17 mm
Series
Book 5 of 29: The Receptors

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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