Fundamental Biomechanics in Bone Tissue Engineering (Synthesis Lectures on Tissue Engineering)

This eight-chapter monograph intends to present basic principles and applications of biomechanics in bone tissue engineering in order to assist tissue engineers in design and use of tissue-engineered products for repair and replacement of damaged/deformed bone tissues. Briefly, Chapter 1 gives an overall review of biomechanics in the field of bone tissue engineering. Chapter 2 provides detailed information regarding the composition and architecture of bone. Chapter 3 discusses the current methodologies for mechanical testing of bone properties (i.e., elastic, plastic, damage/fracture, viscoelastic/viscoplastic properties). Chapter 4 presents the current understanding of the mechanical behavior of bone and the associated underlying mechanisms. Chapter 5 discusses the structure and properties of scaffolds currently used for bone tissue engineering applications. Chapter 6 gives a brief discussion of current mechanical and structural tests of repair/tissue engineered bone tissues. Chapter 7 summarizes the properties of repair/tissue engineered bone tissues currently attained. Finally, Chapter 8 discusses the current issues regarding biomechanics in the area of bone tissue engineering. Table of Contents: Introduction / Bone Composition and Structure / Current Mechanical Test Methodologies / Mechanical Behavior of Bone / Structure and Properties of Scaffolds for Bone Tissue Regeneration / Mechanical and Structural Evaluation of Repair/Tissue Engineered Bone / Mechanical and Structural Properties of Tissues Engineered/Repair Bone / Current Issues of Biomechanics in Bone Tissue Engineering

Dr. Xiaodu Wang is Professor of Mechanical & Biomedical Engineering at the University of Texas at San Antonio (UTSA). He obtained his Doctor degree in Mechanical Engineering and Materials Science at Yokohama National University, Japan in 1990. Prior to joining UTSA in 1999, Dr. Wang was an Assistant Professor (Research) of Orthopaedic Bioengineering in the Orthopaedic Department at the University of Texas Health Science Center at San Antonio. His current research interest is in the areas of biological tissue mechanics, bone remodeling, and nano biomechanics. Dr. Jeffry S. Nyman is a Research Scientist at the Tennessee Valley Healthcare System within the U.S. Department of Veterans Affairs. His primary academic appointment, Research Assistant Professor, is in the Department of Orthopaedics and Rehabilitation at Vanderbilt Medical Center with a secondary appointment in the Department of Biomedical Engineering at Vanderbilt University. Working with his colleagues at the Vanderbilt Center for Bone Biology, Dr. Nyman investigates the role of certain genes (e.g., ATF4, BMP-2, MMP-2 and -9, and NF1) in regulating the inherent quality of bone tissue. This work is a continuation of his graduate studies at the University of California, Davis, and post-doctoral studies at UTSA in bone adaptation and age-related changes in bone toughness. Dr. Xuanliang Dong is currently a Research Assistant Professor in the Department of Mechanical Engineering at UTSA. Dr. Dong got his Ph.D. degree in mechanical engineering from Columbia University in New York City and did his post-doctoral fellowship at Henry Ford Health System in Detroit and University of California at Davis. His current research area is in orthopaedic biomechanics. Dr. Huijie Leng is currently an Associate Professor in the Department of Orthopaedics at Peking University Third Hospital, Beijing, China. Dr. Leng received his Ph.D. degree in the mechanical degree from The University of Notre Dame, USA. He did his post-doctoral research at the University of Texas at San Antonio, USA. Currently Dr. Leng is focusing on the research of clinical biomechanics and mechanics of biomaterials. Michael J. Reyes, M.S.M.E, is a Ph.D. Candidate and Graduate Research Assistant in the Biomedical Engineering Department of UTSA, working on the project that studies age-related changes in bone remodeling and its effect on the mechanical and compositional properties of bone. Before joining UTSA, Mr. Reyes worked as a research engineer in an engineering consulting firm and earned experiences in the design and testing of engineering systems and products.