GPCR Signalling Complexes - Synthesis, Assembly, Trafficking and Specificity

Language: English

Published by Springer, Springer Nov 2012, 2012

9400747640 / 9789400747647

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This item is printed on demand - Print on Demand Titel. Neuware -Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again Pharmacological chaperones may just be part of the answer to this question.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 308 pp. Englisch.…

Seller Inventory # 9789400747647

Title
GPCR Signalling Complexes - Synthesis, Assembly, Trafficking and Specificity
Author
Denis J. Dupré
Publisher
Springer, Springer Nov 2012
Publication year
2012
Condition
Neu
Binding
Buch
Language
English
ISBN 10
9400747640
ISBN 13
9789400747647
Item weight
629 grams
Dimensions
241x160x22 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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