Gain of Function (The MIT Press Essential Knowledge series)

Evans, Nicholas G.

ISBN 10: 0262551357 / ISBN 13: 9780262551359

Published by The MIT Press, 2025

About this Item

Seller Inventory # IN-6226368-9780262551359

Bibliographic Details

• Title: Gain of Function (The MIT Press Essential Knowledge series)
• Publisher: The MIT Press
• Publication Date: 2025
• Language: English
• ISBN 10: 0262551357
• ISBN 13: 9780262551359
• Binding: paperback
• Condition: New

About this title

Synopsis

How a small number of risky experiments creates many unwieldy problems for life science research.


The life sciences have never been more critical to human health, wealth, and security. But with any endeavor comes risk, and the last decade has seen concerns raised about gain-of function-research in which a microbe, usually a virus, is given new properties like enhanced lethality, transmissibility, or the capability to infect new species. In 2021 the term seeped into the tabloids when a conflict between Senator Rand Paul and Dr. Anthony Fauci arose over the origins of COVID-19. In Gain of Function, Nicholas Evans—who has spent his career studying gain-of-function research—describes what this kind of research is, what it isn’t, and why a small number of scientific experiments continues to make headlines.

Evans begins with a description of what gain-of-function research is in science, and what it means in government policy. He tells the story of the original papers that sparked controversy more than a decade ago, unpacking them for readers unfamiliar with virology research, and he identifies where and why policymakers and scientists alike became concerned. He then turns to the history of policies that attempt to regulate gain-of-function research, the current controversies, and the ethics of risky research. He concludes with the future of gain of function, including how debates about gain of function will influence science and public health in years to come.

About the Author

Nicholas G. Evans is Associate Professor and Chair of the Department of Philosophy at the University of Massachusetts Lowell. He is the author of War on All Fronts: A Theory of Health Security Justice.