Gene Transfer in the Cardiovascular System | Experimental Approaches and Therapeutic Implications

Keith L. March

ISBN 10: 1461378818 / ISBN 13: 9781461378815

Published by Springer Nature B.V., 2012

About this Item

Gene Transfer in the Cardiovascular System | Experimental Approaches and Therapeutic Implications | Keith L. March | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2012 | Springer Nature B.V. | EAN 9781461378815 | Verantwortliche Person für die EU: Springer Heidelberg, Tiergartenstr. 17, 69121 Heidelberg, buchhandel-buch[at]springer[dot]com | Anbieter: preigu.

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Bibliographic Details

• Title: Gene Transfer in the Cardiovascular System | Experimental Approaches and Therapeutic Implications
• Publisher: Springer Nature B.V.
• Publication Date: 2012
• Language: English
• ISBN 10: 1461378818
• ISBN 13: 9781461378815
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 29D millimeters 235 millimeters width by 155 millimeters height by 29 millimeters depth
• Weight: 809 grams
• Seller catalogs:
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About this title

Synopsis

The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: • size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . • potential tumorigenesis (e. g. retrovirus) • potential for insertional mutagenesis (greater than plasmid based systems) • potential imrnunogenicity (e. g.