Gene Transfer in the Cardiovascular System

Language: English

Published by Springer US, Springer US Mär 1997, 1997

0792398599 / 9780792398592

Series: Book 99 of 253 - Developments in Cardiovascular Medicine

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This item is printed on demand - Print on Demand Titel. Neuware -The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled 'Artificial Self-Assembling Systems for Gene Transfer', brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: ¿ size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . ¿ potential tumorigenesis (e. g. retrovirus) ¿ potential for insertional mutagenesis (greater than plasmid based systems) ¿ potential imrnunogenicity (e. g. 540 pp. Englisch.

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Title
Gene Transfer in the Cardiovascular System
Author
Keith L. March
Publisher
Springer US, Springer US Mär 1997
Publication year
1997
Condition
Neu
Binding
Buch
Language
English
ISBN 10
0792398599
ISBN 13
9780792398592
Item weight
1,068 grams
Dimensions
241x160x38 mm
Series
Book 99 of 253: Developments in Cardiovascular Medicine

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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AbeBooks seller since January 23, 2017

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