Hardcover. Signalling by morphogens such as the Hedgehog family, Notch, Wingless/Wnt and various growth factors is essential during embryogenesis. The establishment of concentration gradients of these morphogens plays a key role during developmental patterning in all multicellular organisms, assuring that distinct cell/tissue types and organs appear at the right place in the right time during embryogenesis. Regulation of morphogen synthesis, trafficking and diffusion are all known to play a part in setting up these gradients, and a complex web of signaling mechanisms ensures that specific responses occur at the correct threshold concentration in the recipient cells whose fate depends on these morphogens. Signalling by morphogens such as the Hedgehog family, Notch, Wingless/Wnt and various growth factors is essential during embryogenesis. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Bibliographic Details

Title: Generation and Interpretation of Morphogen Gradients (Hardcover)
Publisher: Cold Spring Harbor Laboratory Press,U.S., New York
Publication Date: 2010
Language: English
ISBN 10: 0879698810
ISBN 13: 9780879698812
Binding: Hardcover
Condition: new

About this title

Synopsis

Signaling by diffusible morphogens, such as Hedgehog, Wingless, TGF-�, and various growth factors, is essential during embryogenesis. The establishment of concentration gradients of these morphogens is vital for developmental patterning, ensuring that distinct differentiated cell types appear in the right place and at the right time in forming tissues.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology explores how morphogen gradients are generated and interpreted during development. The contributors examine the regulation of morphogen synthesis, trafficking, and diffusion, as well as the complex webs of signaling mechanisms and transcriptional responses in recipient cells --whose fates are dictated by these morphogens. Including discussion of the roles of morphogen gradients in various tissues in organisms from yeast to humans, the volume is a vital reference for developmental biologists and cell biologists wishing to know how cell fate is determined during embryogenesis.

About the Author

Edited by James Briscoe, MRC National Institute for Medical Research, Peter A. Lawrence, University of Cambridge, and MRC Laboratory of Molecular Biology, and Jean-Paul Vincent, MRC National Institute for Medical Research

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