Genetic Control of Neuronal Migrations in Human Cortical Development

Language: English

Published by Springer, 2006

3540366881 / 9783540366881

Series: Book 10 of 173 - Advances in Anatomy, Embryology and Cell Biology

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Druck auf Anfrage Neuware - Printed after ordering - 1 Introduction Cortical development is a complex, tightly regulated process that eventually leads to the six-layered adult human neocortex, the substrate of the unique cognitive, emotional, and social abilities of our species. The basic mechanisms of early cortical development are believed to be very similar among mammals, which has led to a tendency of extrapolating experimental data from rodents on humans. Certain traits, such as the general pattern of forebrain regionalization and expression of region-speci c genes, seem to be conserved among vertebrates (e. g. , Kammermeier and Reichert 2001; Puelles et al. 2000; Smith Fernandez et al. 1998; Abu-Kahlil et al. 2004). Furthermore, the idea of a basic uniformity of neocortical structure in all mammals, proposed by Rockel et al. (1980), has found wide acceptance. One of the recurrent themes of this monograph deals with exactly these questions: How similar are the developmental processes in lower mammals and in primates, in particular, in humans Are there peculiarities in human cortical development which do not exist, or are not easily recognizable, in rodents One of the most noticeable changes during evolution has been the dramatic increase in brain size, linked to the capacity to generate more neurons. The p- longed period of neurogenesis in anthropoid primates and humans makes possible a higher number of mitotic cycles, so that each dividing progenitor cell undergoes more rounds of cell divisions (Kornack and Rakic 1998). In mice, cortical p- genitors undergo 11 rounds of cell division (Takahashi et al.

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Title
Genetic Control of Neuronal Migrations in Human Cortical Development
Author
Gundela Meyer
Publisher
Springer
Publication year
2006
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3540366881
ISBN 13
9783540366881
Item weight
207 grams
Dimensions
235x155x8 mm
Series
Book 10 of 173: Advances in Anatomy, Embryology and Cell Biology

AHA-BUCH GmbH

Einbeck, Germany

5-star seller

AbeBooks seller since August 14, 2006

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