Genome Damage: Repair and Adaptation Across Life

Genome Damage: Repair and Adaptation Across Life explores the significance of nucleic acid damage from environmental pollutants, UV radiation, and other stressors that can lead to mutations, genetic instability, and various diseases, including cancer. This book delves into the mechanisms of DNA and RNA repair, which are crucial for maintaining cellular health and enabling evolutionary adaptations. It examines these intricate processes across microbes, plants, and animals, providing a comprehensive understanding of how genetic materials are regulated and repaired under diverse environmental conditions.

Other sections cover a wide range of topics, including advanced molecular mechanisms of nucleotide repair, UV-induced damage, apoptosis cell death and autophagy, genetic instability in crops, and the role of post-translational modifications in DNA repair, the detection and quantification of DNA damage, the impact of synthetic chemicals and climate change on nucleic acids, and the therapeutic significance of DNA repair mechanisms. The book closes with a look towards future perspectives.

• Covers nucleic acid damage and repair mechanisms across a range of organisms
• Provides insights into environmental adaptability and the evolutionary significance of genetic mutations
• Discusses detection and prevention strategies for DNA damage
• Offers therapeutic applications for genetic disorders, including cancer and aging-related diseases

Dr. Vinod Kumar Kannaujiya is an assistant professor in the Department of Botany, MMV, Banaras Hindu University, India. He earned his MSc and PhD degrees in Botany from the Centre of Advanced Study in Botany, Banaras Hindu University. He has been working on the ultraviolet stress response of cyanobacteria including value-added enzymes, proteins, pigments, and natural compounds. He has been awarded with prestigious fellowships from the Council of Scientific and Industrial Research, New Delhi, India. He has also been awarded the Dr. D.S. Kothari Post-Doctoral Fellowship from University Grant Commission, New Delhi, India, and he has received a UGC-Startup project grant from UGC, New Delhi, India. Dr. Kannaujiya is a life member fellow of the Indian Photobiology Society. Thus far, Dr. Kannaujiya has published over 49 original research papers, reviews, and book chapters.

Dr. Ganesh Kumar Maurya is an assistant professor in the Department of Zoology, MMV, Banaras Hindu University, Varanasi, India. He received his M.Sc. degree in Zoology from the Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, India and Ph.D. in Life Science from Bhabha Atomic Research Centre, HBNI, Mumbai, India. He has been working on genome maintenance under oxidative stress including Gamma radiation in the polyextremophile Deinococcus radiodurans. Beside this, he is also working on the antibiotic resistance and phage therapy against the pathogenic bacteria. He has received gold medals in M.Sc. and Ph.D. He is the recipient of a prestigious ‘Young Scientist Award from National Academy of Sciences, India’. He is also the recipient of UGC-Startup, SRG-SERB, IoE project grant from various funding agencies. He is a life member fellow of the Society of Biological Chemist (India). He has published over 25 original research papers, reviews, and book chapters.

Dr. Rajesh P Rastogi is currently working as a Scientist/Joint Director at the Ministry of Environment, Forest and Climate Change, New Delhi, India. He completed his Ph. D. on UV-induced DNA Damage and Repair at Banaras Hindu University, Varanasi, India. Dr. Rastogi is the recipient of some national and international awards and fellowships. He was a visiting scientist at Friedrich Alexander University, Nuremberg, Germany and served as a visiting professor of biochemistry at Chulalongkorn University, Thailand. His major research areas are freshwater or marine algae and cyanobacterial ecology and biotechnology, plant physiology, photochemistry, photobiology, molecular microbiology and stress biology. Dr. Rastogi has already published more than 100 referred international peer reviewed research papers, review articles in high impact journals of international repute. He has also published several book chapters and five books from renowned international publishers (Elsevier/Springer/Nova). He is serving as an editorial board member of some national and international journals and is life member of several scientific organizations.