Dans ce livre, nous �tudions les g�nes impliqu�s dans la carcinogen�se buccale et leur utilisation en th�rapie g�nique. La carcinogen�se est un processus complexe en plusieurs �tapes dans lequel les �v�nements g�n�tiques au sein des voies de transduction du signal r�gissant la physiologie cellulaire normale sont modifi�s quantitativement. La base g�n�tique du cancer est d�sormais bien �tablie. Dans des conditions normales, ces voies excitatrices et inhibitrices �troitement contr�l�es r�gulent la biologie des k�ratinocytes oraux. Les fonctions cellulaires de base sous ces contr�les comprennent la division cellulaire, la diff�renciation, la s�nescence et l'adh�sion. Des facteurs g�n�tiques tels que les oncog�nes, les g�nes suppresseurs de tumeurs et les g�nes r�gulateurs sont identifi�s comme �tant impliqu�s dans la carcinogen�se buccale, ces facteurs de risque �tant d�pendants et ind�pendants. Les miARN et Ras Oncog�nes sont parmi les plus fr�quemment d�r�gul�s g�n�tiquement dans le cancer de la bouche. La th�rapie g�nique contre le cancer repr�sente la majorit� des essais cliniques de th�rapie g�nique. Les cibles pour cela comprennent le remplacement des g�nes suppresseurs de tumeurs, les � g�nes suicide � pour activer des prom�dicaments, le transfert de g�nes antiangiog�niques bas� sur les kines.

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