Grafting of Bioactive Polymers to Create Biomimetic Surfaces : Study of the Biological Mechanisms from the Origin of the Observed Activity

Language: English

Published by LAP LAMBERT Academic Publishing, 2017

3330062665 / 9783330062665

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - The use of the titanium (including the alloy Ti6Al4V) in the biomedical field is not new. In fact, it has been extensively used for more than 50 years. Still, in its ordinary form, titanium-based materials can slowly induce the formation of a fibrous layer, even after several years of implantation, compromising the interface with the living tissue and leading to the progressive loss of osteointegration. The inability of titanium to establish strong chemical bonds with the biological material is at the origin of such problems. We proposed the functionalization of the alloy Ti6Al4V with bioactive polymers, namely poly(sodium styrene sulfonate), by chemical grafting to overcome these issues. MC3T3-E1 osteoblast-like cells were culture on these biofunctionalized surfaces and their response, in the presence and absence of important adhesive proteins, was followed both in vitro and in vivo. With this approach we intended to accommodate, at the surface of the biomaterial, the chemical and protein bases required to achieve a 'perfect' control of the cell behavior at the interface, without inducing a cytotoxic response.

Seller Inventory # 9783330062665

Title
Grafting of Bioactive Polymers to Create Biomimetic Surfaces : Study of the Biological Mechanisms from the Origin of the Observed Activity
Author
Helena P. Felgueiras
Publisher
LAP LAMBERT Academic Publishing
Publication year
2017
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3330062665
ISBN 13
9783330062665
Item weight
304 grams
Dimensions
220x150x13 mm

AHA-BUCH GmbH

Einbeck, Germany

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AbeBooks seller since August 14, 2006

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