Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Biostatistics Series)

Jennison, Christopher; Turnbull, Bruce W.

ISBN 10: 0849303168 ISBN 13: 9780849303166

Published by Chapman and Hall/CRC, 1999

Language: English

Condition: New Hardcover

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Bibliographic Details

Title

Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Biostatistics Series)

Publisher

Chapman and Hall/CRC

Publication Date

1999

Language

English

ISBN 10

0849303168

ISBN 13

9780849303166

Binding

Hardcover

Condition

New

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About this title

Synopsis

Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool.

About the Author

Christopher Jennison, Bruce W. Turnbull

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