Guide to Organic Stereochemistry: From Methane to Macromolecules

Takes the reader step-by-step from the structures of simple molecules, such as methane, to the basic shapes of biologically important macromolecules, such as proteins and nucleic acids. Deals with the concept of chirality, which is often overlooked by many texts. Chirality is approached by firstly explaining the stereochemistry of compounds with one stereogenic centre, then dealing with compounds having two or more stereogenic centres before focusing on compounds possessing axes of chirality. The importance of stereochemistry in a wide variety of transformations (for example addition reactions, eliminations, and cycloadditions), is discussed. The final chapters describe the application of stereocontrol in asymmetric synthesis, indicating the use of chiral auxiliaries and chiral catalysts in modern chemistry.

Guide to Organic Stereochemistry uniquely blends all aspects of organic stereochemistry required by undergraduates and postgraduates in chemistry, biochemistry and other life sciences.

It takes the reader step-by-step from the structures of simple molecules, such as methane, to the basic shapes of biologically important macromolecules, such as proteins and nucleic acids. The concept of chirality is dealt with by firstly explaining the stereochemistry of compounds with one stereogenic centre, then dealing with compounds having two or more stereogenic centres before focusing on compounds possessing axes of chirality. The importance of stereochemistry in a wide variety of transformations (for example addition reactions, eliminations, and cycloadditions), is discussed. The final Chapters of Guide to Organic Stereochemistry describe the application of stereocontrol in asymmetric synthesis, indicating the use of chiral auxiliaries and chiral catalysts in modern chemistry.

Key Features:

- Provides a detailed nomenclature of chiral compounds
- Begins with a review of basic principles and terminology, and goes on to cover more advanced topics - suitable for both the the newcomer and also the more experienced organic chemist
- Includes460 clear diagrams - helping the student assimilate complex information
- Questions (and answers) included to help clarify complex issues

S. R. Buxton is Managing Editor, Organic Publications, Royal Society of Chemistry, UK. Through her role at the Royal Society of Chemistry, Dr Buxton is in a unique position to provide an authoritative text, particularly on the usage of nomenclature and stereochemical terminology. S.M. Roberts is Heath Harrison Professor of Organic Chemistry and Chiroscience Professor of Bioorganic Chemistry at the University of Liverpool, UK. His interests include the asymmetric synthesis of biologically active compounds and enzyme chemistry.