A Guide to Protein Structure Prediction: Structure prediction of Retinitis Pigmentosa 1 Protein: A Bioinformatic Approach

Zahra, Sana

ISBN 10: 3659119512 / ISBN 13: 9783659119514

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: A Guide to Protein Structure Prediction: Structure prediction of Retinitis Pigmentosa 1 Protein: A Bioinformatic Approach
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659119512
• ISBN 13: 9783659119514
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

Retinitis pigmentosa (RP) is a group of inherited diseases that damage rod and cone cells located in human retina. A nonsense mutation R677X has been identified in RP1 gene which not only causes mRNA degradation but also results in truncated protein production leading towards visual disparity in humans. Secondary structure of RP1 gene was determined in order to elucidate the structural changes conferred due to nonsense mutation R677X. The structural differences among non mutated and mutated RP1 gene range from 23% to 43%. Similarly the truncated protein also resulted in the loss of certain functional as well as active sites which were identified by predicting motifs. A detailed comparison between non mutated and mutated RP1 gene revealed the significance of R677X mutation causing significant structural (helix, sheet and coil) as well as functional loss. This is useful for future work for annotating the functions of protein using their structures.

About the Author

OBJECTIVE:In quest of an exigent, progress oriented profession within a vibrant & progressive organization with passion, zest, perseverance and striving the best through native abilities.DISTINCTION:Received “Honorary Dr.” title at TWOWS Fourth General Assemblyand International Conference Women Scientists in a Changing World 27-30 June 2010 China