HANDBOOK OF LABORATORY ANIMAL SCIENCE, VOLUME III, THIRD EDITION (HB 2014)

While replacing and reducing the use of laboratory animals are integral parts of the 3Rs―replace, reduce, refine―which form the cornerstones of laboratory animal science, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Building upon the bestselling previous edition, the Handbook of Laboratory Animal Science, Volume III, Third Edition: Animal Models complements volumes I and II of the third edition by completing the task of providing a comprehensive overview of animal models in all biomedical disciplines.

The three Rs have been integrated throughout this handbook to promote efficient and humane experimental work with animals. Written by international experts, each chapter focuses on an important subdiscipline of laboratory animal science and can be used as a stand-alone text. This volume contains new chapters for six additional disease animal models: spinal cord injury, cardiovascular diseases, sudden infant death syndrome, developmental disorders, eye diseases, and human cancer. It also presents a new chapter on applying reduction and refinement to animal models.

This handbook can be used for undergraduate and postgraduate laboratory animal science courses, and as a handbook for scientists who work with animals in their research, for university veterinarians, for regulators, and for other specialists in laboratory animal science.

Jann Hau is a professor of comparative medicine at the University of Copenhagen in Denmark. Dr. Hau has published more than 200 peer-reviewed papers in comparative medicine and chapters in books, and he is frequently invited to speak at international conferences and symposia. He is the recipient of prizes awarded for his research and contributions to animal welfare.

Steven J. Schapiro is an associate professor of comparative medicine in the Department of Veterinary Sciences at the Michale E. Keeling Center for Comparative Medicine and Research of the University of Texas M. D. Anderson Cancer Center. He is one of the founding faculty members of the Primate Training and Enrichment Workshops. Dr. Schapiro has published approximately 140 peer-reviewed papers and book chapters examining various aspects of nonhuman primate behavior, management, and research.