UV AND HPLC Method Development and Method Validation of Nevirapine: UV AND HPLC Method Development and Validation of Nevirapine in Bulk and Pharmaceutical dosage forms

Choudhury, Tirthankar

ISBN 10: 6200218099 / ISBN 13: 9786200218094

Published by LAP LAMBERT Academic Publishing, 2019

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Bibliographic Details

• Title: UV AND HPLC Method Development and Method Validation of Nevirapine: UV AND HPLC Method Development and Validation of Nevirapine in Bulk and Pharmaceutical dosage forms
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2019
• Language: English
• ISBN 10: 6200218099
• ISBN 13: 9786200218094
• Binding: paperback
• Condition: New
• Book Type: book

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Synopsis

This research work focused on UV and RP-HPLC method and method validation of Nevirapine accurately and economically. UV spectrophotometric method and mehod development for Nevirapine obeyed Beer's law as depicted by linearity of the developed method. A reverse phase HPLC (RP-HPLC) method is described for the determination of nevirapine in tablet dosage forms. Chromatography was carried on an ODS column using a mixture of methanol and water (89:11 v/v) as the mobile phase at a flow rate of 1 mL/min with detection at 284 nm. The method was validated by determining its sensitivity, accuracy and precision. The proposed method is simple, economical, fast, accurate and precise, hence can be applied for routine quality control of nevirapine in bulk and tablet dosage forms.