HPLC Method Validation Benzofuran Derivatives: Synthesis and HPLC Method validation of Novel 3-Fluoro-N-{[7-methoxy-2-(4-methoxyphenyl-1-benzofuran-5-yl]methyl}aniline

Thorat, Bapu, Yamgar, Ramesh, More, Kishor

ISBN 10: 3846519669 / ISBN 13: 9783846519660

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: HPLC Method Validation Benzofuran Derivatives: Synthesis and HPLC Method validation of Novel 3-Fluoro-N-{[7-methoxy-2-(4-methoxyphenyl-1-benzofuran-5-yl]methyl}aniline
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3846519669
• ISBN 13: 9783846519660
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

Number of methods are known for the the synthesis of the natural product 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde are known. It is conveniently synthesized by using Intramolecular Wittig reaction of ester. Reductive amination is one of the versatile method for the synthesis of secondary or tertiary amines from aldehydes or ketones by using suitable reducing agent in one-pot fashion. This reaction has been carried out at room temperature and in acidic medium (by using acetic acid). 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde was reacted with 3-fluoroaniline in ethylene dichloride in presence of catalytic amount of acetic acid forming 3-fluoro-N-{[7-methoxy-2-(4-methoxyphenyl)-1-benzofuran-5-yl]methyl}aniline. It is novel benzofuran amine. It's HPLC method validation has been carried out and apply to series of compounds.

About the Author

He is Assistant Professor in Chemistry working under Higher Education Department, Government of Maharashtra, Maharashtra State, India. He is In-charge of Post Graduate and Research Center, Department of Chemistry, Ismail Yusuf College, Mumbai, India 400060. He has published 16 International/National Research papers on various topics.