HPLC Method Validation Benzofuran Derivatives | Synthesis and HPLC Method validation of Novel 3-Fluoro-N-{[7-methoxy-2-(4-methoxyphenyl-1-benzofuran-5-yl]methyl}aniline

Bapu Thorat (u. a.)

ISBN 10: 3846519669 / ISBN 13: 9783846519660

Published by LAP Lambert Academic Publishing, 2012

About this Item

HPLC Method Validation Benzofuran Derivatives | Synthesis and HPLC Method validation of Novel 3-Fluoro-N-{[7-methoxy-2-(4-methoxyphenyl-1-benzofuran-5-yl]methyl}aniline | Bapu Thorat (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783846519660 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 106131027

Bibliographic Details

• Title: HPLC Method Validation Benzofuran Derivatives | Synthesis and HPLC Method validation of Novel 3-Fluoro-N-{[7-methoxy-2-(4-methoxyphenyl-1-benzofuran-5-yl]methyl}aniline
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3846519669
• ISBN 13: 9783846519660
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

Number of methods are known for the the synthesis of the natural product 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde are known. It is conveniently synthesized by using Intramolecular Wittig reaction of ester. Reductive amination is one of the versatile method for the synthesis of secondary or tertiary amines from aldehydes or ketones by using suitable reducing agent in one-pot fashion. This reaction has been carried out at room temperature and in acidic medium (by using acetic acid). 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde was reacted with 3-fluoroaniline in ethylene dichloride in presence of catalytic amount of acetic acid forming 3-fluoro-N-{[7-methoxy-2-(4-methoxyphenyl)-1-benzofuran-5-yl]methyl}aniline. It is novel benzofuran amine. It's HPLC method validation has been carried out and apply to series of compounds.

About the Author

He is Assistant Professor in Chemistry working under Higher Education Department, Government of Maharashtra, Maharashtra State, India. He is In-charge of Post Graduate and Research Center, Department of Chemistry, Ismail Yusuf College, Mumbai, India 400060. He has published 16 International/National Research papers on various topics.