Title: A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
Publisher: John Wiley & Sons Inc
Publication Date: 2014
Language: English
ISBN 10: 1118487680
ISBN 13: 9781118487686
Binding: Hardback
Condition: New
Weight: 847 grams

About this title

Synopsis

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology.

Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry
Helps chemists generate and screen novel chemical libraries of large size and quality
Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery
Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods

About the Author

ROBERT A. GOODNOW, JR. is the Executive Director of the Chemistry Innovation Centre, Discovery Sciences at AstraZeneca and the Founder of GoodChem Consulting, LLC. He has extensive experience in drug discovery and chemistry technologies including carbohydrate, combinatorial, oligonucleotide, and analytical chemistry. Robert Goodnow has authored or coauthored nearly 100 publications and patents and has spoken extensively on the topics of drug lead finding and the outsourcing of drug discovery chemistry. He has lectured as an adjunct professor of medicinal chemistry.

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