The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell secretome-based cell-free strategies in regenerative medicine. The chapters in section I and section II respectively discuss the diverse applications of mesenchymal stem cells and non- mesenchymal stem cells, including skeletal myoblasts, endothelial progenitor cells, adipose tissue-derived stem cells, induced pluripotent stem cells, and neuronal stem cells in myocardial repair, inflammatory bowel disease, cognitive deficits, wound healing, retinal disorders, and COVID-19. The subsequent chapters in section IIIprimarily focused on the fast-emerging cell-free therapy approach in regenerative medicine for tissue repair and regeneration. These chapters review the impact of stem cell-derived secretome on various biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, musculoskeletal pathologies, wound healing, anti-fibrotic, and anti-tumorigenesis for tissue maintenance and regeneration.Lastly, section IV summarizes miscellaneous aspects of cell-based therapy, includingthe treatment advantages, opportunities, and shortcomings in stem cell-based therapy, potentially helping to refine future studies and translate them from experimental to clinical studies. Moreover, this section also has chapters on cancer stem cells as novel targets in cancer therapeutics. This Major Reference Book (MRW) is a valuable resource for researchers involved in stem cell research to understand the multifaceted therapeutic applications of stem cells and their derivative secretome in regenerative medicine.
Dr. Khawaja Husnain Haider is currently a Professor of Cellular and Molecular Pharmacology (Stem cells and Gene Therapy) and Chairman of the Basic Sciences Department (Medical Program) at Sulaiman AlRajhi University. He has also served as Principal Investigator (PI) and Co-PI on various NIH-funded stem cells research projects. He has been on the editorial boards of various research journals and has served as an invited reviewer for several respected international journals. His research focuses on the use of DNA, miRNAs, and stem cells as “drugs,” a topic that has gained popularity in regenerative medicine. He has published more than 300 book chapters, abstracts, and research papers published in various books and leading research journals, including Circulation, Circulation Research, Cardiovascular Research, Journal Cellular and Molecular Medicine (JCMM), the Journal of Biological Chemistry, Cell Cycle, Basic Research in Cardiology, and Antioxidant Redox Signaling. He has alsogiven numerous presentations and edited seven books covering various facets of stem cells and their applications from drug to drug development.
