Title: Hemoglobin and Its Diseases (Cold Spring Harbor Perspectives in Medicine)
Publisher: Cold Spring Harbor Laboratory Press
Publication Date: 2013
Language: English
ISBN 10: 1936113457
ISBN 13: 9781936113453
Binding: Hardcover
Condition: New

About this title

Synopsis

Hemoglobin is an iron-containing protein in red blood cells that transports oxygen to tissues throughout the body. The abundance, stability, and oxygen-carrying properties of hemoglobin can be altered by genetic mutations. More than one thousand hemoglobin disorders are known; hemoglobinopathies (e.g., sickle cell disease) and thalassemias are some of the most common human genetic diseases worldwide.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of hemoglobin and its diseases. Contributors examine the structure, expression, and evolution of the globin genes, the assembly of globin subunits into functional forms of hemoglobin, and the numerous variants that result from genetic alterations. The pathophysiological consequences of hemoglobin disorders (e.g., ineffective erythropoiesis and aberrant iron homeostasis), their clinical manifestations, and epidemiological trends are also described.

This volume includes discussions of management and treatment strategies for hemoglobin disorders, such as transfusions, iron-chelating agents, gene therapy, and stem cell transplantation. It is an indispensable reference for biochemists, geneticists, cell and developmental biologists, physiologists, and all who are interested in reducing the medical burden of these common genetic diseases.

About the Author

Sir David John Weatherall, GBE, FRS (9 March 1933-8 December 2018) was a British physician and researcher in molecular genetics, haematology, pathology and clinical medicine.

"About this title" may belong to another edition of this title.

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