The Herg Cardiac Potassium Channel: Structure, Function and Drug-Induced Long Qt Syndrome

Goode, J

ISBN 10: 0470021403 / ISBN 13: 9780470021408

Published by John Wiley and Sons, 2005

About this Item

This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In poor condition, suitable as a reading copy. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,700grams, ISBN:9780470021408.

Seller Inventory # 5574240

Bibliographic Details

• Title: The Herg Cardiac Potassium Channel: Structure, Function and Drug-Induced Long Qt Syndrome
• Publisher: John Wiley and Sons
• Publication Date: 2005
• Language: English
• ISBN 10: 0470021403
• ISBN 13: 9780470021408
• Binding: Hardcover
• Condition: Poor
• Weight: 700 grams
• Seller catalogs:
  • Medicine

About this title

Synopsis

This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. 

It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. 

Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.

About the Author

The Novartis Foundation is an international scientific and educational charity that promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.