Heterogeneity in Asthma

Allan R. Brasier

ISBN 10: 1461486025 / ISBN 13: 9781461486022

Published by Springer US, Springer New York, 2013

About this Item

Druck auf Anfrage Neuware - Printed after ordering - Asthma is a chronic relapsing airways disease that represents a major public health problemworldwide. Intermittent exacerbations are provoked by airway mucosal exposureto pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representingthe two most common precipitants. In this setting, inducible signaling pathwaysthe airway mucosa play a central role in the initiation of airway inflammationthrough production of antimicrobial peptides (defensins), cytokines, chemokinesand arachidonic acid metabolites that coordinate the complex processes ofvascular permeability, cellular recruitment, mucous hyper-secretion, bronchialconstriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into thesubmucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, itis well appreciated that asthma is a heterogeneous in terms of onset,exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focuson a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensionalprofiling in asthma. This book willoverview multidimensional profiling strategies and visualization approaches forphenotyping asthma. As an outcome, thiswork will facilitate the understanding of disease etiology, prognosis and/ortherapeutic intervention.

Seller Inventory # 9781461486022

Bibliographic Details

• Title: Heterogeneity in Asthma
• Publisher: Springer US, Springer New York
• Publication Date: 2013
• Language: English
• ISBN 10: 1461486025
• ISBN 13: 9781461486022
• Binding: Buch
• Condition: Neu
• Dimensions: 241W x 160H x 26D millimeters 241 millimeters width by 160 millimeters height by 26 millimeters depth
• Weight: 717 grams

About this title

Synopsis

Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling.  These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response.  Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease.  An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma.  This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma.  As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. ​