Highly Selective Separations in Biotechnology

G. Street

ISBN 10: 9401045763 / ISBN 13: 9789401045766

Published by Springer, Springer Sep 2012, 2012

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -Success in meeting the challenge to produce the commercial products anticipated by the exploitation of biological processes depends upon provid ing effective separation protocols. Effectiveness can be measured in terms of selectivity, purity, resolution and validatory success. The major processing problems are associated with either the selective recovery of molecules which are present in low concentrations from complex mixtures or the selective removal of contaminants from the desired molecule. Central to the evolution of processes satisfying this demand are the regulatory requirements being imposed by governments on the purity of a product, especially in the health care market. Synthetic organic chemists are increasingly finding it advantageous to conduct one or more steps using either enzymic biotransformations where molecules with a single and consistent stereochemistry or chirality are required. The underlying princi ples behind the methods, techniques and processes currently being used and developed commercially rely upon the biospecific nature and properties of the desired molecule. When these factors are married to the more traditional techniques of precipitation, chromatography, liquid-liquid extraction and membrane processes, powerful tools emerge, allowing highly selective separations to be designed. The logical extension of these combinations is to apply genetic engineering techniques to influence the separations at a more fundamental and structural level by modifying the target protein at source, during its synthesis, to facilitate its separation in a given, selective manner, leading to the distinct possibility of producing 'designer' separation programmes.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 248 pp. Englisch.

Seller Inventory # 9789401045766

Bibliographic Details

• Title: Highly Selective Separations in Biotechnology
• Publisher: Springer, Springer Sep 2012
• Publication Date: 2012
• Language: English
• ISBN 10: 9401045763
• ISBN 13: 9789401045766
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 14D millimeters 235 millimeters width by 155 millimeters height by 14 millimeters depth
• Weight: 382 grams

About this title

Synopsis

Success in meeting the challenge to produce the commercial products anticipated by the exploitation of biological processes depends upon provid­ ing effective separation protocols. Effectiveness can be measured in terms of selectivity, purity, resolution and validatory success. The major processing problems are associated with either the selective recovery of molecules which are present in low concentrations from complex mixtures or the selective removal of contaminants from the desired molecule. Central to the evolution of processes satisfying this demand are the regulatory requirements being imposed by governments on the purity of a product, especially in the health care market. Synthetic organic chemists are increasingly finding it advantageous to conduct one or more steps using either enzymic biotransformations where molecules with a single and consistent stereochemistry or chirality are required. The underlying princi­ ples behind the methods, techniques and processes currently being used and developed commercially rely upon the biospecific nature and properties of the desired molecule. When these factors are married to the more traditional techniques of precipitation, chromatography, liquid-liquid extraction and membrane processes, powerful tools emerge, allowing highly selective separations to be designed. The logical extension of these combinations is to apply genetic engineering techniques to influence the separations at a more fundamental and structural level by modifying the target protein at source, during its synthesis, to facilitate its separation in a given, selective manner, leading to the distinct possibility of producing 'designer' separation programmes.

From the Back Cover

This book primarily concentrates on the larger molecules of immediate therapeutic interest - usually protein in nature, since these are currently at the forefront of commercial development - but chapters on molecular imprinting and chiral separations explore the opportunities available for the highly selective separation of small molecules. This is a book for biotechnologists, chemical engineers and biochemists in the academic world and industry.