Histocompatibility Antigens : Structure and Function

B. Parham

ISBN 10: 940095896X / ISBN 13: 9789400958968

Published by Springer Netherlands, 2013

About this Item

Druck auf Anfrage Neuware - Printed after ordering - The Major Histocompatibility Complex (MHC) was discovered as a con sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A.

Seller Inventory # 9789400958968

Bibliographic Details

• Title: Histocompatibility Antigens : Structure and Function
• Publisher: Springer Netherlands
• Publication Date: 2013
• Language: English
• ISBN 10: 940095896X
• ISBN 13: 9789400958968
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 229W x 152H x 15D millimeters 229 millimeters width by 152 millimeters height by 15 millimeters depth
• Weight: 388 grams

About this title

Synopsis

The Major Histocompatibility Complex (MHC) was discovered as a con­ sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans­ planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A.